Microdosing has long been explored as a tool for cognitive enhancement, emotional regulation, and neuroplasticity. While protocols such as James Fadiman’s one-day-on, two-days-off cycle or Paul Stamets’ four-days-on, three-days-off regimen provide structured approaches to microdosing, I wanted to explore a method that aligns with something even more fundamental—the natural rhythms of the moon.
This Lunar Microdosing Protocol is my interpretation of the Stamets Stack, integrating psilocybin with Lion’s Mane and Niacin while syncing the dosing schedule with the four major phases of the moon. The goal is to enhance neurogenesis, emotional awareness, and creativity while maintaining a balanced cycle of growth, reflection, and integration.
The lunar cycle is one of the oldest natural rhythms, influencing everything from ocean tides to human sleep cycles, emotions, and cognitive patterns. Many ancient cultures have recognized the moon’s role in energy shifts, introspection, and renewal, and modern research suggests that biological processes—including serotonin regulation and sleep-wake cycles—may be subtly influenced by lunar rhythms.
✔ Enhance neuroplasticity by following a structured yet organic dosing rhythm.
✔ Avoid tolerance buildup through natural breaks in the cycle.
✔ Maximize creativity and problem-solving when the brain is primed for expansion.
✔ Support emotional integration during reflective lunar phases.
This protocol follows the four major moon phases, each lasting approximately seven days, and adjusts the microdosing schedule accordingly.
The new moon represents beginnings, clarity, and intention-setting. It’s the perfect time to start a microdosing cycle, allowing psilocybin to stimulate new neural pathways while Lion’s Mane supports nerve regeneration.
Day 1 (New Moon): Microdose + Set intentions for the cycle
Days 2-4: Microdose (with Lion’s Mane & Niacin)
Days 5-7: Rest & Integration (journaling, meditation, self-reflection)
Focus: Cognitive expansion, setting goals, new perspectives
This phase is all about taking action, making progress, and engaging in deep work. The brain is primed for problem-solving and learning, making this an ideal time for those working on creative or intellectually demanding projects.
Days 8-10: Microdose
Days 11-14: Rest & Integration
Focus: Heightened focus, productivity, deep engagement with work
The full moon is known for heightened consciousness, introspection, and emotional depth. This is a great time to lean into self-awareness, emotional breakthroughs, and deep inner work.
Day 15 (Full Moon): Microdose + Mindfulness practice (meditation, gratitude, or journaling)
Days 16-18: Microdose
Days 19-21: Rest & Integration
Focus: Emotional intelligence, subconscious exploration, self-reflection
As the lunar cycle comes to an end, this phase is about winding down, stabilizing neural changes, and reflecting on progress. It’s the perfect time for a longer break, allowing the brain to fully integrate the neurogenic benefits of the past weeks.
Days 22-23: Microdose
Days 24-29: Full Rest Period
Focus: Evaluating progress, grounding, preparing for the next cycle
By mirroring the moon’s natural energy shifts, the protocol guides users through periods of neuroplastic growth and introspective recovery. Instead of a rigid schedule, this cyclical approach ensures that the mind has time to expand, process, and integrate insights.
Long-term microdosing requires careful management of tolerance levels. By incorporating longer breaks toward the end of the cycle, this protocol ensures that the brain remains receptive to psilocybin’s benefits without diminishing effects over time.
Many creatives experience natural fluctuations in focus, motivation, and inspiration. The lunar cycle provides a built-in rhythm that aligns with creative bursts (First Quarter Moon) and deep reflection (Full Moon), helping individuals optimize cognitive and emotional states for different kinds of work.
Psychedelics can facilitate profound emotional and psychological shifts. However, without proper integration, these insights may fade or feel disconnected from daily life. The rest days and extended breaks in this protocol ensure that users can process their experiences fully, leading to more meaningful long-term benefits.
If you’re interested in trying this approach, follow these steps:
Psilocybin: 0.1g - 0.3g dried mushrooms
LSD: 5-10 micrograms
Lion’s Mane: 500mg - 1000mg
Niacin (Flush version): 50mg - 200mg
Begin on the New Moon
Track your experience daily (mood, focus, creativity, emotional state)
Adjust dosage if needed based on sensitivity and effects
New Moon: Set intentions, visualize goals
First Quarter: Deep work, creative projects
Full Moon: Meditation, emotional processing
Last Quarter: Reflection, journaling, integration
Consider how the cycle impacted your creativity, focus, and emotional well-being.
Adjust your next cycle based on insights gained.
This Lunar Microdosing Protocol offers a unique, natural approach to psychedelic microdosing. Inspired by Paul Stamets’ emphasis on neurogenesis, this schedule ensures that cognitive growth occurs in balance with periods of rest and reflection. By syncing microdosing with the lunar cycle’s natural rhythm, we create a structured yet organic path for mental clarity, emotional resilience, and personal transformation.
For those who feel drawn to nature’s cycles, creative flow, and deeper self-awareness, this approach provides a sustainable and intuitive way to integrate microdosing into daily life. After all, if the moon influences the tides and the very rhythms of life on Earth, why not allow it to guide the ebb and flow of our own consciousness? 🌙