Lunar Stamets

The Lunar Microdosing Protocol: A Cyclical Approach to Cognitive Growth and Emotional Balance

Microdosing has long been explored as a tool for cognitive enhancement, emotional regulation, and neuroplasticity. While protocols such as James Fadiman’s one-day-on, two-days-off cycle or Paul Stamets’ four-days-on, three-days-off regimen provide structured approaches to microdosing, I wanted to explore a method that aligns with something even more fundamental—the natural rhythms of the moon.

This Lunar Microdosing Protocol is my interpretation of the Stamets Stack, integrating psilocybin with Lion’s Mane and Niacin while syncing the dosing schedule with the four major phases of the moon. The goal is to enhance neurogenesis, emotional awareness, and creativity while maintaining a balanced cycle of growth, reflection, and integration.

Why Align Microdosing with the Lunar Cycle?

The lunar cycle is one of the oldest natural rhythms, influencing everything from ocean tides to human sleep cycles, emotions, and cognitive patterns. Many ancient cultures have recognized the moon’s role in energy shifts, introspection, and renewal, and modern research suggests that biological processes—including serotonin regulation and sleep-wake cycles—may be subtly influenced by lunar rhythms.

By aligning microdosing with this cycle, we can:

✔ Enhance neuroplasticity by following a structured yet organic dosing rhythm.

✔ Avoid tolerance buildup through natural breaks in the cycle.

✔ Maximize creativity and problem-solving when the brain is primed for expansion.

✔ Support emotional integration during reflective lunar phases.

This protocol follows the four major moon phases, each lasting approximately seven days, and adjusts the microdosing schedule accordingly.

The Lunar Microdosing Protocol (Inspired by Stamets’ Stack)

🌑 New Moon Phase (Days 1-7) — Intention & Neurogenesis Initiation

The new moon represents beginnings, clarity, and intention-setting. It’s the perfect time to start a microdosing cycle, allowing psilocybin to stimulate new neural pathways while Lion’s Mane supports nerve regeneration.

Dosing Schedule: 4 days on, 3 days off

Focus: Cognitive expansion, setting goals, new perspectives

🌒 First Quarter Moon (Days 8-14) — Expansion & Creative Flow

This phase is all about taking action, making progress, and engaging in deep work. The brain is primed for problem-solving and learning, making this an ideal time for those working on creative or intellectually demanding projects.

Dosing Schedule: 3 days on, 4 days off

Focus: Heightened focus, productivity, deep engagement with work

🌕 Full Moon Phase (Days 15-21) — Peak Awareness & Emotional Clarity

The full moon is known for heightened consciousness, introspection, and emotional depth. This is a great time to lean into self-awareness, emotional breakthroughs, and deep inner work.

Dosing Schedule: 4 days on, 3 days off

Focus: Emotional intelligence, subconscious exploration, self-reflection

🌗 Last Quarter Moon (Days 22-29) — Grounding & Integration

As the lunar cycle comes to an end, this phase is about winding down, stabilizing neural changes, and reflecting on progress. It’s the perfect time for a longer break, allowing the brain to fully integrate the neurogenic benefits of the past weeks.

Dosing Schedule: 2 days on, 5 days off

Focus: Evaluating progress, grounding, preparing for the next cycle

Why This Approach Works

1. It Balances Expansion and Recovery

By mirroring the moon’s natural energy shifts, the protocol guides users through periods of neuroplastic growth and introspective recovery. Instead of a rigid schedule, this cyclical approach ensures that the mind has time to expand, process, and integrate insights.

2. It Prevents Tolerance Buildup

Long-term microdosing requires careful management of tolerance levels. By incorporating longer breaks toward the end of the cycle, this protocol ensures that the brain remains receptive to psilocybin’s benefits without diminishing effects over time.

3. It Supports Creativity and Productivity Cycles

Many creatives experience natural fluctuations in focus, motivation, and inspiration. The lunar cycle provides a built-in rhythm that aligns with creative bursts (First Quarter Moon) and deep reflection (Full Moon), helping individuals optimize cognitive and emotional states for different kinds of work.

4. It Encourages Emotional and Spiritual Integration

Psychedelics can facilitate profound emotional and psychological shifts. However, without proper integration, these insights may fade or feel disconnected from daily life. The rest days and extended breaks in this protocol ensure that users can process their experiences fully, leading to more meaningful long-term benefits.

How to Implement the Lunar Microdosing Protocol

If you’re interested in trying this approach, follow these steps:

Choose Your Microdose:

Follow the Lunar Schedule:

Engage in Supportive Practices:

Assess and Adjust:

A Harmonized Approach to Microdosing

This Lunar Microdosing Protocol offers a unique, natural approach to psychedelic microdosing. Inspired by Paul Stamets’ emphasis on neurogenesis, this schedule ensures that cognitive growth occurs in balance with periods of rest and reflection. By syncing microdosing with the lunar cycle’s natural rhythm, we create a structured yet organic path for mental clarity, emotional resilience, and personal transformation.

For those who feel drawn to nature’s cycles, creative flow, and deeper self-awareness, this approach provides a sustainable and intuitive way to integrate microdosing into daily life. After all, if the moon influences the tides and the very rhythms of life on Earth, why not allow it to guide the ebb and flow of our own consciousness? 🌙