Paul Stamets, a world-renowned mycologist and advocate for medicinal mushrooms, developed a unique microdosing regimen known as the Stamets Stack. His approach goes beyond just taking small amounts of psilocybin—he combines it with Lion’s Mane mushroom and Niacin (vitamin B3) to create a synergistic effect aimed at brain regeneration, cognitive enhancement, and overall neurological health.
Let’s break it all down:
Unlike traditional microdosing protocols that focus mainly on mood and creativity, the Stamets Stack is specifically designed to promote neurogenesis (the growth of new neurons) and synaptogenesis (the formation of new connections between neurons).
Stimulates the 5-HT2A serotonin receptor, which enhances neuroplasticity.
Encourages growth and repair of neural pathways, especially in areas linked to memory and cognition (like the hippocampus).
Shown to improve creativity, problem-solving, and mood regulation.
Contains compounds like hericenones and erinacines, which stimulate Nerve Growth Factor (NGF).
NGF helps repair damaged neurons, making it potentially beneficial for conditions like Alzheimer’s and Parkinson’s.
Enhances focus, memory, and mental clarity.
Helps psilocybin and Lion’s Mane reach deeper into the nervous system, especially the peripheral nervous system.
Causes flushing (a warm, red sensation on the skin), which some believe improves blood flow and nutrient delivery to the brain.
Works as a vasodilator, helping expand blood vessels and reduce inflammation.
Unlike the Fadiman protocol (which has a one-day-on, two-days-off cycle), the Stamets Stack follows a four days on, three days off routine:
Day 1: Microdose
Day 2: Microdose
Day 3: Microdose
Day 4: Microdose
Days 5-7: Rest (to prevent tolerance)
The four-day "on" phase is believed to give the brain sustained exposure to the neurogenic effects of the stack, while the three-day "off" phase prevents desensitization to psilocybin’s effects.
Stimulates brain cell regeneration, potentially improving memory and learning.
Increases focus and problem-solving skills.
May help slow cognitive decline in aging individuals.
Psilocybin’s effects on serotonin can help reduce anxiety and depression.
May support emotional resilience by rewiring negative thought patterns.
Helps create new neural pathways, which is beneficial for conditions like PTSD and OCD.
Lion’s Mane’s NGF-stimulating properties can repair damaged neurons, making it promising for neurodegenerative diseases.
Potential for stroke recovery and neuroinflammation reduction.
Psilocybin enhances divergent thinking, leading to new ideas and insights.
Many report an improved ability to think outside the box and enter flow states.
While the Stamets Stack has promising benefits, it’s not for everyone. Here are some things to keep in mind:
Niacin Flushing: The warm, tingly skin sensation from niacin can be uncomfortable but is harmless. If it’s too intense, some people reduce the dose.
Psilocybin Sensitivity: Some individuals may feel more anxiety or overstimulation with psilocybin. If that happens, lower the dose.
Not Ideal for All Mental Health Conditions: Those with bipolar disorder or schizophrenia should avoid psilocybin, as it may trigger manic or psychotic episodes.
More Research Needed: While studies support psilocybin’s effects on neurogenesis, long-term human trials are still in early stages.
If you’re considering trying the Stamets Stack, here’s a general guideline:
Psilocybin: 0.1g to 0.3g (100mg to 300mg) dried mushrooms per dose
Lion’s Mane: 500mg to 1000mg per dose
Niacin (Flush version): 50mg to 200mg per dose
Start low and slow, then adjust based on how you feel.
Keep a journal to note changes in mood, focus, creativity, and emotions.
Be mindful of how your body and mind respond over time.
If you experience any discomfort, adjust the dose or take longer breaks.
If your goal is cognitive enhancement, neuroprotection, and long-term brain health, the Stamets Stack is one of the most scientifically intriguing microdosing protocols out there. Unlike the Fadiman approach, which focuses more on mood and creativity, Stamets’ regimen aims for actual brain growth and repair.
However, it’s important to listen to your body, start slow, and always prioritize safety. While Stamets’ theories on neurogenesis are promising, further scientific studies are needed to fully validate these claims.